At the top tier of posh regarding Berlin lodging, the Adlon is about as centrally located from a tourist standpoint as you can get. Try and get a room that faces the Brandenburg Gate. Has an amazing breakfast buffet as well.
Embracing life in Berlin and everything it has to offer. I enjoy the openness that comes with the variety of neighborhoods tucked between the crisscrossing U-Bahn, S-Bahn, and tram lines.