What was once the Royal Danish Embassy now stands as an imposing hotel in the diplomatic district of Tiergarten. Enjoy the opulence you'd expect from a luxury hotel (spa, pool, libraries), plus private entrance into the zoo next door.
By perfect accident, the Michelberger became the de-facto lodging for musicians operating in East Berlin. Though it's a popular place to end off debaucherous jaunts in the city, the hotel's homely vibe is perfectly suited to families too.
Right in the middle of Kreuzberg, Hotel Orania is universally reviled by locals due to its elitist status, nestled in among a more down-to-earth part of Berlin. It is a nice hotel though with a good restaurant and solid bar.
While it's primarily a hotel, 25Hours is also a hotspot for locals who come for drinks and live music at the rooftop Monkey Bar, or for Moroccan food at Neni. The rooms themselves are bright and have views of either the city or Berlin zoo.
Your classic Ritz-Carlton style property. Close to Potsdamer Platz, the Tiergarten, and other Berlin sightseeing.